The fundamental manifestations of neuromuscular disease in the newborn period are hypotonia and weakness. Newborn children with extreme hypotonia but only marginal weakness usually do not have a disorder of the lower motor unit. These babies may have hereditary conditions; metabolic unsettling influences; inherent coronary illness; muscular dystrophy; sepsis; hypothyroidism; spinal muscular atrophy; or other fundamental issue. Extremely reduced antigravity movements and reduced fetal movements and abnormal liquor were frequent but not present consistently in infants with neuromuscular disorders. The most reliable indicators of a neuromuscular disorders are severe muscular weakness and contractures.
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